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Publications

2024:

Michael Mykins, Benjamin Bridges, Angela Jo, Keerthi Krishnan. “Multidimensional analysis of a social behavior identifies regression and phenotypic heterogeneity in a female mouse model for Rett syndrome”, Journal of Neuroscience

2023:

Michael Mykins, Benjamin Bridges, Angela Jo, Keerthi Krishnan. “Multidimensional analysis of a social behavior identifies regression and phenotypic heterogeneity in a female mouse model for Rett syndrome”, bioRxiv, June 2023. Manuscript at review in a traditional journal.

Brett Emery*, Matthew Everett*, Logan R. Dunn, Billy You Bun Lau, Keerthi Krishnan. “CDKL5 deficiency results in atypical subregion-specific expression of perineuronal nets during mouse visual critical period”, bioRxiv, May 2023 – Revision. * — Co-first authors for their considerable contributions to the manuscript. Manuscript at review in a traditional journal.

Michael Mykins*, Dana Layo-Carris D*, Logan R. Dunn*, David Wilson Skinner, Sarah Perez, Alexandra McBryar, Trinity Rose Shultz, Andrew Willems, Billy Y.B. Lau, Tian Hong, Keerthi Krishnan. “Wild-type MECP2 expression coincides with age-dependent sensory deficits in a female mouse model for Rett syndrome”. Journal of Neuroscience Research.

Kevin Luxem, Jennifer J Sun, Sean P Bradley, Keerthi Krishnan, Eric Yttri, Jan Zimmerman, Talmo D Pereira, Mark Laubach. “Open-source tools for behavioral video analysis: Setup, methods, and best practices”. eLife.

Michael Mykins, Krista Marrero, Giuseppe Cataldo, Krithiga Aruljothi, Keerthi Krishnan, Joshua C. Brumberg. “Barrels XXXV: barrels in-person”. Somatosensory & Motor Research.

2022:

Brett Emery *, Matthew Everett *, Billy You Bun Lau, Keerthi Krishnan. “CDKL5 deficiency results in atypical subregion-specific expression of perineuronal nets in the mouse primary visual cortex”, bioRxiv, September 2022. * — Co-first authors for their considerable contributions to the manuscript.

Michael Mykins*, Dana Layo-Carris*, Logan Dunn*, David Wilson Skinner, Sarah Perez, Alexandra McBryar, Trinity Rose Shultz, Andrew Willems, Billy You Bun Lau, Tian Hong, Keerthi Krishnan. “Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndrome”, bioRxiv, April 2022. * — Co-first authors for their considerable contributions to the manuscript.

Kevin Luxem, Jennifer J. Sun, Sean P. Bradley, Keerthi Krishnan, Talmo D. Pereira, Eric A. Yttri, Jan Zimmermann, Mark Laubach. ” Open-source tools for behavioral video analysis: Setup, Methods and Development”. arXiv, April 2022.

2021:

Michael Mykins, Eric Espinoza-Wade, Xu An, Billy You Bun Lau, Keerthi Krishnan. “Key kinematic features in early training predict performance of adult female mice in a single pellet reaching and grasping task”, bioRxiv, May 2021.

Parker Stevenson *, Devin M. Casenhiser*, Billy Y.B. Lau, Keerthi Krishnan. “Systematic analysis of goal-related movement sequences during maternal behavior in a female mouse model for Rett syndrome,” European Journal of Neuroscience, May 2021. * – Equal contribution

Zachary A Grieb, Emma G Ford, Mahircan Yagan, Billy YB Lau, Fredric P Manfredsson, Keerthi Krishnan, Joseph S Lonstein. “Oxytocin receptors in the midbrain dorsal raphe are essential for postpartum maternal social and affective behaviors,” Psychoneuroendocrinology, Accepted June 2021. Volume 131, September 2021.

2020:

Undergraduate student authors in purple
  • Stevenson P*, Casenhiser D*, Krishnan K. “Systematic analysis of goal-related movement sequences during maternal behavior in a female mouse model for Rett syndrome”, bioRxiv preprint, December 2020.    * co-first authors.

  • Lau BYB, Layo DE, Emery B, Everett M, Kumar A, Stevenson P, Reynolds KG, Cherosky A, Bowyer SH, Roth S, Fisher D, McCord RP, Krishnan K. “Lateralized expression of cortical perineuronal nets during maternal experience is dependent on MECP2″. eNeuro April  2020. bioRxiv preprint in September 2019.

eNeuro considered this paper to be noteworthy and featured this work on the “Research Spotlight” section, for the week of May 12th.

  • Lau BYB, Krishnan K, Huang ZJ, Shea SD. “Maternal experience-dependent cortical plasticity in mice is circuit- and stimulus-specific and requires MECP2”. The Journal of Neuroscience, February 2020, bioRxiv, July 2019

Featured in February’s roundup of most-discussed articles, with altmetric score of 58, scored at top 5%.

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Krishnan (Pre-UTK):

  1.  Krishnan K*$, Lau BYB*, Ewall G, Huang ZJ, Shea SD. “MECP2 regulates cortical plasticity underlying a learned behavior in adult female mice”. Nature Communications, 2017, 8, 14077 doi: 10.1038/ncomms14077. Preprint available at bioRxiv doi: http://dx.doi.org/10.1101/041707.

$-Corresponding author. *-Equal contribution

  1. Krishnan K*, Wang BS*, Lu J, Wang L, Maffei A, Cang J, Huang ZJ. “MECP2 regulates the timing of critical period plasticity that shapes functional connectivity in the primary visual cortex.” PNAS 2015, August 25,  112 no. 34 E4782-E4791.  * – Equal contribution

  2. Krishnan N, Krishnan K, Connors CR, Choy MS, Page R, Peti W, Van Aelst L, Shea SD, Tonks NK. “PTP1B inhibition suggests a therapeutic strategy for Rett Syndrome”. Journal of Clinical Investigation 2015; 125(8):3163-3177.

  3. Lazarus MS, Krishnan K, Huang ZJ. “GAD67 deficiency in Parvalbumin interneurons produces deficits in inhibitory transmission and network disinhibition in mouse prefrontal cortex.” Cerebral Cortex, 2015; 25 (5):1290-1296, first published online November 24, 2013.

  4. Krishnan K, Salomonis N, Guo S. “Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo,” PLoS ONE, 2008. 3(11): e3621.

  5. Shen WF, Chrobak D, Krishnan K, Lawrence HJ, Largman C. “HOXB6 protein is bound to CREB-binding protein and represses globin expression in a DNA binding-dependent, PBX interaction-independent process,” Journal of Biological Chemistry. 279(38):39895-904. 2004

  6. Shen WF, Krishnan K, Lawrence HJ, Largman C. “The HOX homeodomain proteins block CBP histone acetyltransferase activity,” Molecular Cellular Biology, 21(21): 7509-7522.

Lau (Pre-UTK):

  1. Cazakoff BN, Lau BY, Crump KC, Demmer HS and Shea SD. Broadly tuned and respiration independent inhibition in the mouse olfactory bulb.  Nature Neuroscience 17, 569-576 (2014).

  2. Lau BY, Fogerson SM, Walsh RB and Morgan JR. Cyclic AMP promotes axon regeneration, lesion repair and neuronal survival in lampreys after spinal cord injury.  Experimental Neurology 250, 31-42 (2013).

  3. Lau BYB and Morgan JR. “Fishing” for new strategies to improve recovery.  Paraplegia News June (2011).

  4. Lau BY, Foldes AE, Alieva NO, Oliphint PA, Busch DJ and Morgan JR. Increased synapsin expression and neurite sprouting in lamprey brain after spinal cord injury.  Experimental Neurology 228, 283-293 (2011).

  5. Lau BY, Mathur P, Gould GG, and Guo S. Identification of a brain center whose activity discriminates a choice behavior in zebrafish.  Proceedings of the National Academy of Sciences 108, 2581-2586 (2011).

  6. Mathur P, Lau B and Guo S. Conditioned place preference behavior in zebrafish.  Nature Protocols 6, 338-345 (2011).

  7. Lau B, Bretaud S, Huang Y, Lin E and Guo S. Dissociation of food and opiate preference by a genetic mutation in zebrafish.  Genes, Brain, and Behavior 5, 497-505 (2006).

 

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